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【福可维 盐酸安罗替尼胶囊】价格_功效与副作用_说明书-康德乐大药房

  

  ҩƷܲʾ緢ֱվκֱӻ۴ҩΪ뱣֤ݣ12331ٱٱʵ轱


  ƷΪҩɹԤչʾҩƷҩݴ˽ϵ Э벦


  ҩƷ涨ͨȡʽύ󵽵깺򣬲Ҫ¼ǼϱϢ 밴ҩƷ˵ҩʦָ¹ʹãݻע˵顣


  ƷӦпҩʹþҽָʹã1Ƽ÷ᰲƼΪÿ12mgÿ1Σǰڷҩ2ܣͣҩ1ܣ3ܣ21죩ΪһƳֱ̣չֲܵIJӦҩڼ©ȷϾ´ҩʱ12Сʱٲ2ƷʹùӦмⲻӦݲӦеʹܹơƷµIJӦ֢ͨƣͣҩͣȷʽݲӦ̶ȣҽʦָµٵһε10mgÿһΣ2ܣͣҩ1ܣڵڶε8mgÿһΣ2ܣͣҩҩ1ܣڼο12[ע]8mg޷ܣͣҩdzѪIJӦʱӦձ1ԭмѪIJӦʱձ2м1 ݲӦļԭ2 ѪӦļԭܲȫߵҩĿǰޱƷԸܲȫӰݡٴоʾڷñƷĻ߿ɳָ˺͵жȸܲȫҽʦָñƷضȸܲȫ߽áCYP1A2CYP3A4/5ǿƼյCYP1A2CYP3A4/5ǿƼ绷ɳǻͪ򣩿ӱƷѪŨȣCYP1A2CYP3A4/5յƽܽͱƷѪŨȣCYP1A2CYP3A4Ƽյã[ҩ໥]


  ϸĶ˵鲢ҽʦָʹáݡҩƷӪ淶ҩƷԭ⣬ҩƷһ۳˻


  Ʒҩڼٽܹ2ϵͳƺֽչ򸴷ľֲڻתԷСϸΰߵơڴڱƤ壨EGFRͻܰøALKԵĻߣڿʼƷǰӦӦİҩƺչٽܹ2ϵͳƺֽչ򸴷


  ᰲƼΪÿ12mgÿ1Σǰڷҩ2ܣͣҩ1ܣ3ܣ21죩ΪһƳֱ̣չֲܵIJӦҩڼ©ȷϾ´ҩʱ12Сʱٲ


  ƷʹùӦмⲻӦݲӦеʹܹơƷµIJӦ֢ͨƣͣҩͣȷʽݲӦ̶ȣҽʦָµٵһε10mgÿһΣ2ܣͣҩ1ܣڵڶε8mgÿһΣ2ܣͣҩҩ1ܣڼο12[ע]8mg޷ܣͣҩ


  dzѪIJӦʱӦձ1ԭмѪIJӦʱձ2м


  ĿǰޱƷԸܲȫӰݡٴоʾڷñƷĻ߿ɳָ˺͵жȸܲȫҽʦָñƷضȸܲȫ߽á


  CYP1A2CYP3A4/5ǿƼ绷ɳǻͪ򣩿ӱƷѪŨȣCYP1A2CYP3A4/5յƽܽͱƷѪŨȣCYP1A2CYP3A4Ƽյã[ҩ໥]


  ˵ٴй۲쵽жΪɰIJӦƵķ.ٴڸֲͬ½еģһٴй۲쵽IJӦķʲһٴ۲쵽IJӦֱӱȽϣҲܷܲӳٴʵеʵʷʡ


  񹲻9ٴ835߱¶ڰİȫݣЩ߲ʼΪ12mg2ܣͣҩ1ܵҩЩоܰȫбӦ20ΪѪѹƤӦθӦι쳣״ٹ쳣Ѫ֬͵ȡ


  ڷСϸΰIJӦϢҪһġ˫äοյĢٴ飨 ALTER0303n437Լһġ˫äοյٴ飨 ALTER0302n117


  ALTER0303оٽܹ2ϵͳԻƺչ޷ܵľֲڣתԷСϸΰߣEGFRͻALKԻ߻ܹӦҩƺչܣECOGЭ֯״Ϊ01֣ųгѪҩƲĸѪѹѪ쳣Լ24Сʱ򵰰׶1.0gĻߡ294߷ðƣʼΪ12mgÿһΣڷҩ2ܣͣҩ1


  ܣÿ3ܣ21죩Ϊһڡ57.14168294߽6ڼϵƣ25ߣ8.50˼µ12mgµ10mg31.02˵ڶµ10mgµ8mg¼µҪӦƤӦѪѹкʳǻĤסι쳣򡢸Ѫ֬ͷ


  ϸͰοмӦʷֱΪ97.2888.113ϲӦʷֱΪ47.2818.183г ALTER0303оа밲ο鷢ʡ10IJӦʡ23ϵIJӦNCH- CTC AE4.0ּ


  3 ALTER0303озʡ10зּIJӦ͡23ϲӦܱ


  *еIJӦָ ALTER0303оиожΪ϶޹֮IJ¼г˰鷢밲ο鷢2мIJӦ


  ALTER0303оУ鱨ҪѪ¼ΪѪԵĿѪ黹˱dzѪ134.42Ѫ134.421Ϊ3֧ܳѪ51.70ЩѪʾڰο飬Ϊ12ڰ黹˺Ѫ41.362Ϊ3Ѫ31.021Ϊ3ųѪ20.68Ѫ20.68ӌmѪ۵׳Ѫ10.34Ϊ12ЩѪ¼ڰοδ档Ͱο10.340.70Գ


  ALTER0303оУ鱨31.02ζѪ˨1Ϊ31431.02ǻѪ˨2Ϊ3οδѪ˨˨¼


  бͬҩٴʹпԷβ ALTER0303оС鱨41.36


  Էף210.34331.02οδԷβ¼


   ALTER0303оУ鱨51.70ز¼οδ档


   ALTER0302ٴоĻ ALETR0303ƣ ALTER0302оECOG2ֺͻ״̬ȷĻߣ60ߡܰ12mg2ͣҩ1ܽơͰο鲻ӦʷֱΪ86.6752/6052.6330/57鷢ʡ5IJӦУѪѹ53.33ƤӦ25.0018.33к15.60ǻճĤף13.33ʹ11.67Ƥ10.00ԣ8.33˻ƣ8.33״ٹܼˣ6.87ͿѪ5.00ʵҼ쳣5Ѫټ״ټߣ31.67Ѫߣ18.33Ѫߣ16.6715.00ܶ֬ߣ11.67ãȰתøߣ11.67ALTߣ10.00Ѫߣ6.67оİȫоơ


  ԱƷκγɷݹӦãͷ۰дѪյĻ߽ãضȸܲȫ߽ãPڸŮá


  VEGFRƼҩпӳѪաٴоʾڰο飬˳Ѫ¼ķԵijѪ ALTER0303оУijѪ¼ΪѪ3ϿѪıΪ3.069/2944425οΪ1.40214323ǴDZѪѪdzѪ֧ܳѪѪѪδ۲쵽ԳѪʵӣٴоų֢״Ļ֢״ʱС2תƻߣЩʹðᡣٴҽҩʱӦйע֢״гѪգѪ쳣ӦñƷñƷڼӦܼѪøԭʱ͹ʱ׼ʣINR


  һ2ijѪ¼Ӧͣҩ܃ָܻ2µһҩμ[÷]ٳ֣Ӧͣҩһ3ϵijѪ¼ͣҩ


  ٴų˴ڳѪʼʷҩǰ4ڳ֡ CTCAE3κγѪ¼δϴڡۡ6ڷѪ˨¼Ѫ⣨ʱȱѪԷѪ˨˨ߣ˾ϷյĻӦҽʦָʹãԺûֵĻӦÿ12ܼѪøԭʱĸı䣬INRֵעٴѪ


  ٴоʾӷѪ˨˨¼ķգƷӦھѪ˨вʷĻߣ


  ÿѪҩĻ߻ؼߣҩڼӦܼ⣬緢Ѫ˨زӦͣҩָҩٴγ֣ͣҩ


  Ѫѹ VEGFRƼҩIJӦٴозð˸Ѫѹķ


  ALTER0303ٴоСͰοֱ64.6313.99Ļ߳˸Ѫѹа3913.273Ѫѹ10.344Ѫѹڿʼҩ2ڳ֣ͼ͸ͨ׿ȳ潵ѹҩԿơ


  ʼҩǰ6ӦÿѪѹҩڼÿܼѪѹ23ΣѪѹ߻ͷʹͷ֢״Ӧҽͨҽʦָ½ܽѹҩƣͣƻ


  34Ѫѹѹ180mmHgѹ110mmHgӦͣҩָҩٴγ34ѪѹߣӦµһҩμ[÷]13/4Ѫѹͣҩ


  ӳQTOTcڣ ALTER0303оУĵͼQTͬӳ3ϵΪ2.38οΪ1.40ٴʱ˴ٴʧĻߣOTcڼ䣾480ms


  ԳOTۺĻӦʹñƷгѪ˥ߡ쳣ʹ֪ܹӳQTcڼҩĻӦڣÿ36ܣĵͼECG͵ʣơþغ͸ƣļ⡣ζĵͼʾQTc500msĻӦͣʹñƷֱQTcڡ4B0msʱɻָˮƽmsʱɻָҩӦµһмĵͼ


  ڳκμQTcӳ450msκһĻӦͣñƷŤתĶ١Ķ١ʧ֢״ӦʱѪרơ


  Ĺ쳣ĻߣӦÿ6๦ܼ飬֢/ĹܲȫʳʾѪ50ĻӦͣҩ


  ALTER0303оУתø,߻ܵߡضȸιܻ߽áжȸιܲȫ


  ӦҽʦָȨյ½ҩðʱӦתø͵أƿʼǰÿڡԼٴҪʱιܣALTASTأ߷2ι쳣ʱӦӼƵʣ߷34תøܵʱӦͣҩͬʱÿܼѪתøܵ23Σ2ڻָ2ɻָҩµһҩµ34תø򵨺߳ͣҩμ[÷]1


  ๦쳣 VEGFRƼҩﳣIJӦ֮һ𵰰ALTER0303оа72.383򣬰ο10.73δ4ĵδ3ϵļߡܲȫӦҽʦָðᲢм⡣黼ÿ6ܼ򳣹棬2򵰰סݣߣ24Сʱ򵰰ײⶨݲӦȡͣҩͣҩȴʩμ[÷]1


  ʾƶϸ꣨786QA375A549Caki1U87MGMDAMB231HT29NCIH526HMC1ֳIC5030125uM֮䣺 HUVECSSϸп VEGFR2ữˮƽص׵ữMo7eϸпcKitữˮƽص׵ữU87MGϸпPDGFRữˮƽص׵ữVEGFA̼µ HUVECSEֳǨƣСγɣƴ΢Ѫṹγɡ


  һ㶾SD26ܾڸ谲0.20.83.0mgkgͣҩָ6ܣδӦ NOAELΪ


  08mg/kg㣬ԼΪٴҩ12mgˣ0.653.0mgkgԶԷӦ԰Ϊݺ࣬ BeagleȮ39ܾڸ谲0.020.080.32mgkgͣҩָ6ܣ NOAEL0.02mgkg㣬ԼΪٴҩ12mgˣ0.05ҪԷӦΪС׼̷ԸıŴԣAmes飮йγάϸCHLȾɫԼС΢Ϊԡ


  ֳԣ̥У󾭿ڸ谲0.251.04.0mgkgɼ˫฽غС124΢ǰή1024΢һжȾή1324ɼŴʣʣ̥̣ӹѳϵͣӹ٣ήף̥Ŵǰܶʧߣ̥ͣ NOAELΪ1mgkg㣬ԼΪٴҩ12mg˵08̥̥зУ󾭾ڸ谲0.30.61.8mgkgɼ̥̥ᣬ̥ӣŴʧӣӹᣬ̥и巢С̥̥ӣ179200ֻ2222ѣҪαΪˮסβββ̥ķӣ̥β׵عDZͻƹǺͽָţǹǻ٣̥еڣչǹǣ­ǣ׵׵ȫķӣ߹εķӣ NOAEL03mgkg


  㣬ԼΪٴҩ12mg˵0.25þڸ谲0150309mgkgɼӹ̥ӹ̥ӹѳϵͣŴʽ̥ͣðٷߣ̥̥ͣʧߣ̥зٻͣǻ̶Ƚۣͣ༰·ʻSߣ NOAEL0.15mgkg㣬ԼΪٴҩ12mg˵0.25


  ΧֳУ󾭿ڸ谲0.30.61.8mgkgɼ״ĸ̥̥̥ٷߣؼʳʽͣӴʣɻʣؽͣ״ĸF1 NOAELΪ0.6mgkg㣬ԼΪٴҩ12mg˵0.5ɷڽ֭֭еŨԼΪѪҩŨȵ3050


  //ϩѹ͹ҩøӲƬҩװ7/塢14/壻1/С2/С4/л8/С


  ᰲὺʲôҩܹڷΰ رΰΪּķ൱ߣеӦЩʲôֹּķҲǺܶ˹ĵ⡣ҪҩĻһᰲὺ


  ϷΰȺ𽥵࣬üƴҪպʱܶǶڸü˽ⲻ̫࣬ҪʱҩƣҪ˽һЩƵķעҪϸڣô ᰲὺ÷ʲô?ҩһƳ?


  һа֢һ㶼ҪʱҽԺƵģΰͻߵIJϰйϵһ㻼зΰҪͨɱϸģڻƵʱҲҪʹҩᰲὺƵģôһ ᰲὺҴʲôɣ &nb


  ΰٴһֳԶڴ˵ܶ˵ڸ༲˵ҪĽƵģڸ༲ҩк֣ܶǾ ᰲὺǷʺϷΰҩ ᰲὺ


  ϸΰһҪȷļ⣬ѿܶ˵ĴڣȷʵܻǴdz˺ڸüҩҲdz࣬ô ᰲὺʲôط۸ ᰲὺ


  ÿһ˶ӦҪάԼ彡ÿһ˶ӦҽָȷĽƼǻǾ÷dzʹͻҲӦҪעúõĽдô ᰲὺʲôЩã ᰲ


  άҪԶãƼʱ򣬺ܶಡ˶ȽϹԼõʵʳ̵ģΪܶʵDzϲҩ־ġԣһЩڿڷάʱ򣬶Ҫ֪ҩʱ䡣 ÿһڳҩ


  άҪʲô֢ϣܹƼҩֵģҩ֮࣬ҪΪԲͬļҪʹõҩﶼDzһģԣάҲֻijһЩ֢öѡ


  άʺʲô˳ԣÿʱ򣬶ȵҽԺȷȻרҵʿݲ˵ʵȷҩ˲ʲôҩDzɲԾġ ڷΰ˵


  άʺϷΰ˳𣿷ΰһֺصİ֢һ¶Ҫҩܰ˵ģǷΰҩҲкܶ࣬ǷֱӳԸάҪרҵʿġ ʵһֽ


  𾴵Ĺ˿ͣټý̳ǹҩ֤ҩ꣬סҩƷ׷ʸ֤顷C20110003ڹݰټҩҵ޹˾ʮȫרҩȫ׼רҩȫӵִҵҩʦרעشԼҩ


  ӪģҩҵŹɷ޹˾ ά֤100%ƷͨƷ׼ĺŵʳƷҩƷලվѯάᰲὺңα


  ٲѯָٲѯѡݿֻؼ֣ɶѡݿжݵĿٲѯ£ԹҩƷݿΪ


  


  4. ؼ֣ѯťڲѯбгаùؼ ֵݣһ¼Բ鿴ϸϢ


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